| abstract |
The present invention relates to aminopyrazole derivatives or its acceptable salts and including aminopyrazole derivatives or its acceptable salts pharmaceutical composition as active component.The aminopyrazole derivatives or its acceptable salts represented by chemical formula 1 have good anti-angiogenesis effect in chorioallantoic membrane model, thus it can effectively prevent or treat angiogenesis-associated diseases as medicament, such as macular degeneration or arthritis, the aminopyrazole derivatives or its acceptable salts also have good colitis inhibiting effect in inflammatory bowel disease model, thus it can effectively prevent or treat inflammatory bowel disease as medicament.On the lung carcinoma cell of inoculation in chorioallantoic membrane model, the aminopyrazole derivatives of chemical formula 1 or its acceptable salts inhibit angiogenesis and tumour growth caused by tumour, also it can inhibit the activity of cathepsin S to play an important role in cancer metastasis and invasion, therefore it can be used as cancer to grow and shift effective inhibitor. |