http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105367600-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-683 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-661 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-6615 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-12 |
| filingDate | 2014-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105367600-B |
| titleOfInvention | A kind of curcumin phosphate compounds, Preparation method and use |
| abstract | The present invention relates to a kind of curcumin phosphate compounds, Preparation method and use, belong to medicinal chemistry art.The general structure of the compound is as follows： X is O or S, R 1 And R 2 It is each independently：(1) substitution phosphoric acid and the salt or D2EHDTPA and the salt of ion formation of ion formation, the ion is H + 、NH 4 + Or metal ion；Or (2) and the salt of organic base formation；Or (3) phenyl ring；Or straight chain, side chain or the cyclic alkane base that (4) carbon number is 1~10；Or straight chain, side chain or the cyclic alkane base that the carbon number of in the middle of (5) carbochain or end connection phenyl ring is 1~10.The compound is obtained by curcumin with substitution phosphoryl chloride phosphorus oxychloride through phosphorus acylation reaction.The compound, which has, suppresses transthyretin aggregation activity, can be used as treating the medicine of the amyloidogenic disease related to transthyretin. |
| priorityDate | 2014-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 179.