http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105367456-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C313-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 |
| filingDate | 2015-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105367456-B |
| titleOfInvention | A kind of preparation method of chiral trifluoromethyl allylic amines compound |
| abstract | The invention belongs to organic chemistry filed; provide a kind of preparation method of chiral trifluoromethyl allylic amines compound; the present invention utilizes optically pure α; β unsaturations tert-butyl group sulfenyl ketimide and the Ruppert Prakash reagents of commercialization are raw material; under inert gas shielding; under the catalysis of lewis base; asymmetric trifluoromethylation reaction, the trifluoromethyl allylic amines compound containing four substitution carbon chiral centres of a kind of easily conversion and derivatization is obtained with outstanding cis-selectivity in high yield by the direct regioselectivity of a step.Raw material is conveniently easy to get needed for the present invention, synthetic method is simple to operate, and the reaction time is short, and the yield and optical purity of product are all higher, it is a kind of method of trifluoromethyl allylic amines compound of general preparation containing four substitution carbon chiral centres, there is good application prospect. |
| priorityDate | 2015-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.