http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105367455-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 |
| filingDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105367455-B |
| titleOfInvention | A kind of preparation method of belistat isomer |
| abstract | The invention provides a method for preparing the cis isomer of belinostat, which uses 3-phenylaminosulfonylbenzaldehyde as a starting material, undergoes Wittig condensation reaction, hydrolysis, chlorination reaction, and hydroxylamine condensation reaction to obtain Belinostat and Belinostat isomer mixture, the content of Belinostat cis isomer in the mixture is significantly improved compared with the prior art. The Belinostat and Belinostat isomer mixture obtained in the reaction were separated and purified by reverse-phase high-performance preparative liquid chromatography, and the Belinostat isomer with a purity of more than 99% was obtained in accordance with the requirements of the impurity reference substance in the inspection of Belinostat related substances. |
| priorityDate | 2015-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.