http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105367441-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-86 |
| filingDate | 2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105367441-B |
| titleOfInvention | Novel compounds used in the synthesis of enzalutamide |
| abstract | The present invention provides compound Z-M for synthesizing enzalutamide and its preparation method, wherein, R is selected from allyl, propargyl, benzyl, epoxypropyl or other α, β unsaturated bonds group. Through the new compound Z-M of this series, on the one hand, it is possible to avoid the use of iodine in the preparation of the key intermediate 2-(3-fluoro-4-(methylcarbamoyl)phenylamino) methyl 2-methylpropionate Methane is a toxic reagent. On the other hand, the Edman degradation reaction of the new intermediate Z‑M and isothiocyanate compound 7 to synthesize enzalutamide is better than the reaction conditions of the methyl ester intermediate reported in the original literature. |
| priorityDate | 2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.