| abstract |
The present invention provides chimeric FVII molecules comprising FVII, an XTEN polypeptide, and an antibody and antigen-binding molecules thereof which specifically bind the alpha and/or beta subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties, e.g., half-life extending moiety. The invention also includes methods of producing and using the chimeric molecules. |