http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105348181-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-73 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 |
| filingDate | 2015-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105348181-B |
| titleOfInvention | A kind of preparation method of the bromopyridine of 2 amino, 5 methyl 6 |
| abstract | The defects of it is an object of the invention to overcome in the prior art, there is provided a kind of preparation method of the bromopyridine of 2 amino, 5 methyl 6, belong to medicine intermediate synthesis technical field.This method is：By the organic solvent after water removal under nitrogen protection, Sodamide is added, reheats solution, after the picoline of 2 bromine 3 is added, keeps the temperature reflux to react；After reaction terminates, solution is cooled, moisture on the rocks goes out upper strata organic solvent, organic solvent is concentrated, crystallization obtains product.The present invention directly obtains product, process safety is simple, is adapted to industrialized production by a step amination. |
| priorityDate | 2015-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.