| abstract |
The invention discloses formula (I) compound its pharmaceutically useful salt and ester, in formula (I), R 1 - R 8 、A、B、Z 1 And Z 2 As claim defines.Formula (I) compound has the function that as lyases (CYP17) inhibitor of androgen receptor antagonist (inhibitor) and/or the α hydroxyls enzyme of Cytochrome P450 monooxygenase 17/17,20.Such compound may be used as the medicine for the treatment of cancer, particularly prostate cancer and other male sex hormone dependent conditions for wishing male sex hormone antagonism and disease. |