http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105331616-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105331616-B |
| titleOfInvention | Tetracycline-induced artificial MicroRNA element |
| abstract | The invention discloses a tetracycline-induced artificial MicroRNA element, the nucleotide sequence of which is shown as SEQ NO 1 or SEQ NO 2. The artificial microRNA element can be used for targeting genes of different bladder cancer cell lines, such as a beta-catenin gene, and in the case, the sequence is shown as SEQ NO:1 is shown in the specification; or HIF-1 alpha gene, wherein the sequence is as shown in SEQ NO:2, respectively. The artificial element can effectively inhibit the expression of a target gene in a bladder cancer cell line, can effectively inhibit the proliferation of the bladder cancer cell, promotes the apoptosis of the bladder cancer cell and inhibits the migration of the bladder cancer cell, thereby providing possibility for treating the bladder cancer. |
| priorityDate | 2015-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.