http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105330794-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F120-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F285-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F265-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F226-02 |
| filingDate | 2015-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105330794-B |
| titleOfInvention | Amphipathic nature block polymer and its preparation and application with active-passive dual-target antitumor activity |
| abstract | The invention provides a kind of amphipathic nature block polymer with active-passive dual-target antitumor activity, is that the folic acid of two sulphur monomers of functionalization, modification is connected to a kind of good high-molecular block copolymer --- methacryl SS trimethoxybenzoic acids N (2 hydroxypropyl) the Methacrylamide folic acid copolymer of the bio-compatible formed on N (2 hydroxypropyl) Methacrylamide by RAFT polymerization methodses.The block copolymer of the present invention can be self-assembly of the micellar carrier of core shell structure in water, and disulfide bond is broken in the environment of high reduction in cancer cell so that micellar structure is destroyed, so as to discharge adriamycin（DOX）, further kill cancer cell；Macromolecule carrier PHPMA makes copolymer embody good Bc, reduce further the toxicity of cancer therapy drug, reduces the injury of normal tissue, therefore have good application prospect in antineoplastic is prepared. |
| priorityDate | 2015-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.