| abstract |
Tryptanthrin (indole[2,1-b]quinazoline-6,12-dione) new derivative, synthesis method and medicinal use, <b>has the following general structural formula:</b><b > </b> New derivatives of tryptanthrin were synthesized through biomimetic synthesis. The general chemical formula of these new derivatives is shown in Figure 1, where: R, R 1 , R 2 , R 3 =halogen, nitrate base, amino, hydroxyl, alkyl, alkoxy, etc.; aryl: R 1 = morpholine, piperidine, N-methylpiperidine, N-ethylpiperidine, isopiperidine, piperazine, 1 -(2-pyridyl)piperazine, dimethylamine, diethylamine, 1-(2-hydroxyethyl)piperazine, 1-(2-furoyl)piperazine, derived from anthranilic acid derivatives and Indole quinone derivatives are prepared by reacting in toluene, methanol, ethanol, dichloromethane, isopropanol and other solvents. Through the MTT test and antibacterial test, it has a good inhibitory effect on cancer cells and a good antibacterial effect. A new tryptanthrin compound, which has pharmacological effects in antitumor, antibacterial, and anti-inflammatory aspects. |