http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105330630-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-84 |
| filingDate | 2015-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105330630-B |
| titleOfInvention | Benzofuran compounds and its preparation method and application |
| abstract | The present invention provides a kind of benzofuran compounds and its preparation method and application, shown in its structure such as general formula (I 1) or general formula (I 2)： Wherein, R 1 、R 3 , R 4 For any one in hydrogen, C1 C5 straight or branched alkyls, hydroxyl, aldehyde radical, acetyl group, carboxyl, cyano group, amino, nitro, fluorine, chlorine, bromine, amide groups, ester group, alkoxy, aromatic radical, heteroaryl perfume base；R 2 For hydrogen, C1 C5 straight or branched alkyls, hydroxyl, aromatic radical, heteroaryl perfume base any one；M, n is 05 integer.The present invention is using the substrate polypeptide fragment LPXTG of staphylococcus aureus Sortase A as structural simulation object, simulation substrate proline is used as using benzofuran structure, the amide groups hydrophobic patch simulation substrate leucine residue connected thereon, designs new protease Sortase A inhibitor. |
| priorityDate | 2015-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.