abstract |
The invention discloses a preparation method of optically active 1-cyclohexylethylamine. The preparation method of the present invention comprises the following steps: in water, under the action of HBr, the N-acetylamino-1-cyclohexylethylamine shown in formula 4 or formula 4' is subjected to a hydrolysis reaction, and the corresponding formula 5 or Optically active 1-cyclohexylethylamine represented by formula 5'. The preparation method of the present invention may further include preparing the compound shown in formula 1 through oximation reaction, reductive acylation reaction and asymmetric catalytic reaction to obtain N-acetylamino-1- Cyclohexylethylamine. The preparation method of the invention has the advantages of simple operation, low production cost, high product chemical purity and optical purity, high product yield, and environmental protection. |