http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315343-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 |
| filingDate | 2015-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105315343-B |
| titleOfInvention | Solen active octapeptide and preparation method and application thereof |
| abstract | The invention relates to a solen active octapeptide, the amino acid sequence of which is Ala-Pro-His-Asp-Asp-Gln-Asn-His, and the molecular weight detected by ESI/MS is 933.1 Da; the preparation method comprises the following steps: removing shells of fresh razor clams, taking out the fresh razor clams, cleaning the razor clams, mashing the fresh razor clams, homogenizing tissues, and adjusting the pH value of homogenate for later use; adding alkaline protease into the homogenate for enzymolysis to obtain an enzymolysis sample, performing ultrafiltration and G-25 gel separation reversed-phase high performance liquid chromatography purification on the obtained enzymolysis sample, collecting elution peak components, and performing amino acid sequencing to obtain the solen active octapeptide. The solen active octapeptide has the maximum proliferation inhibition rate of more than 90% on human prostatic cancer PC-3 cells, can provide a theoretical basis for the research of anti-prostatic cancer drugs, is obtained by a biological enzymolysis mode, has wide raw material sources and low cost, and has great significance for further researching and developing solen-based drugs and foods and improving the economic value of the solen. |
| priorityDate | 2015-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.