abstract |
The present invention discloses isoquinoline-3-formyl-Arg(NG-NO 2 )-Val- OBzl . Its preparation method is disclosed, its nanostructure is disclosed, its inhibitory effect on PAD4 is disclosed, its activity of inhibiting tumor cell proliferation is disclosed, and its tumor growth inhibitory activity of inhibiting S180 solid tumor in mice is disclosed . Therefore, the present invention discloses the clinical application prospect of isoquinoline-3-formyl-Arg(NG-NO 2 )-Val- OBzl as an antitumor drug targeting PAD4. |