http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315269-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105315269-B |
| titleOfInvention | Rivaroxaban related substance or its salt, its intermediate, preparation method and use |
| abstract | The invention discloses a rivaroxaban-related substance or a salt thereof, an intermediate thereof, a preparation method and an application thereof. The preparation method of the rivaroxaban related substance as shown in formula I or its hydrochloride disclosed in the present invention includes the following steps: when preparing the compound shown in formula I, the preparation method includes the following steps: in an organic solvent, in a base Under the action of , the compound shown in formula III or its hydrochloride is subjected to acylation reaction with the compound shown in formula IV; when preparing the salt of the compound shown in formula I, the following steps are included: In the solvent, the compound represented by the formula I can be subjected to a salt-forming reaction with an acid. The rivaroxaban-related substances of the present invention are necessary for the quality control of rivaroxaban, and can effectively identify impurities generated in the synthesis of rivaroxaban, thereby controlling the drug quality of rivaroxaban. |
| priorityDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.