http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105315216-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-70 |
| filingDate | 2015-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105315216-B |
| titleOfInvention | Barbiturates-cyclohexene spiro-compound and preparation method thereof |
| abstract | Barbiturates cyclohexene spiro-compound and preparation method thereof.As shown in 3 and 4, the synthetic method of compound 3 is the structural formula of the barbiturates cyclohexene spiro-compound：In dry Shrek pipe, by compound 1 and connection 2 mixing of enester in solvent, organic phosphine catalyst is added, stirs, it is the gained spiro-compound 3 to carry out cycloaddition reaction；The synthetic method of compound 4 is：In dry Shrek pipe, by compound 1 and connection 2 mixing of enester in solvent, chiral organic phosphine catalyst and additive is added, stirring carries out cycloaddition reaction up to the chiral spiro compound 4.The present invention provides a kind of simple and practicable new method for synthesis barbiturates cyclohexene spiro-compound；Method provided by the invention is reacted using cycloaddition mode, belongs to atom economic reaction；The present invention is using organic phosphine as catalyst, rather than with transition-metal catalyst, there is no heavy metal pollutions in product. |
| priorityDate | 2015-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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