abstract |
The invention discloses a guaiac-type sesquiterpene compound, a preparation method and application thereof. Preparation method: (1) Take the finished product of Reduning Injection, separate it by HP-20 macroporous adsorption resin column chromatography, and sequentially elute with water, 30% ethanol, and 90-100% ethanol gradient, collect each eluate separately, Concentrate to obtain 90-100% ethanol elution site; (2) 90-100% ethanol elution site, followed by silica gel column chromatography, Sephadex? LH-20 column chromatography, ODS column chromatography separation, semi-preparative liquid phase HPLC separation, to obtain the new compound of the present invention. The compound of the present invention can be used for treating hand, foot and mouth disease. |