http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105301155-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 |
| filingDate | 2015-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105301155-B |
| titleOfInvention | A kind of method of tanshinone IIA sodium sulfonate concentration in measure human plasma |
| abstract | The invention belongs to field of medical examination, it is related to the analysis determining method of internal medicine, and in particular to a kind of method for determining tanshinone IIA sodium sulfonate concentration in human plasma.This method uses deuterium 5 to take off dehydroepiandros-sterone sodium sulfate salt (DHEAS D5) for internal standard, used in blood sample processing procedure without the control STS degradeds of ultraviolet gold-tinted safety lamp (light for removing below 420nm wavelength) condition, the degree of accuracy of ensuring method；Quantitative organic solvent methanol and acetonitrile mixture protein precipitation are added after being acidified blood sample using formic acid, tanshinone IIA sodium sulfonate and interior target concentration are determined using tandem mass spectrometry, quantitative linearity scope is 2 1000ng/mL, can meet the requirement of human pharmacokineticses research；This method sample is few, and pretreatment is simple, quick, sensitive, it is only necessary to which universal equipment and reagent, analytical cycle is short, and cost is low, is suitable for the monitoring of the routine clinical blood concentration of tanshinone IIA sulfonic acid. |
| priorityDate | 2015-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.