| abstract |
The present invention discloses a kind of jamaicin double salt, specially jamaicin oleanolic acid salt or jamaicin ursolic acid salt, its preparation method is to act on oleanolic acid or ursolic acid with sodium hydroxide in ethanol solution, it is made again with berberine salt reactant aqueous solution, jamaicin oleanolic acid salt, jamaicin ursolic acid salt are insoluble in water, lipophilicity, without bitter taste；Jamaicin and oleanolic acid, ursolic acid are all the native chemical compositions for having valuable pharmacological activity, and both are combined into ion-pair compound, can play the effect of bigger, especially suitable for oral cavity, mucous membrane and pediatric pharmaceuticalses；Medicine source of the present invention is enriched, and prepares simply, cost is low, and toxic side effect is small；Jamaicin oleanolic acid salt, jamaicin ursolic acid salt have following structural formula respectively： 。 |