http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105294562-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_331e38ffbbd507f0d1394c4b56600dca |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 |
| filingDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adb513119ccf114e03fa73295396b496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c900502dd4cfa2e88f2a2bda23c8e151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12079af0811c61f81d5ca133d5a8b594 |
| publicationDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105294562-A |
| titleOfInvention | A kind of preparation method of 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine |
| abstract | The invention belongs to the field of organic synthesis, in particular to a method for synthesizing the key intermediate of tolvaptan, 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine , including the synthesis of A, 5-chloro-2-(diallylamino)-benzaldehyde, B, 1-allyl-7-chloro-2,3,4,5-tetrahydro-1H-2,5 -Synthesis of epoxybenzo[b]azepine, C,1-allyl-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine Synthesis of D, 7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine in four steps; the process route adopts substitution, cyclization, opening The key intermediate of tolvaptan is synthesized by the four-step reaction of cyclization and deprotection. The synthesis steps are few, the operation is simple, the equipment requirements are low, and the yield of each step is high. The four-step reaction does not require column chromatography separation. The method has the advantages of simple process, convenient industrial scale production and low cost. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108383848-A |
| priorityDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.