http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105273063-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2015-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105273063-B |
| titleOfInvention | Adjust polypeptide and its application of FGFR1 activity |
| abstract | The invention discloses a kind of polypeptide R1 P1 for adjusting FGFR1 (fibroblast growth factor acceptor 1) activity, it can specifically bind with FGFR1, and there is apparent adjustment effect to its activity, the activity of p ERK in FGFR1 major downstream signal paths MAPK can be significantly inhibited, energy conspicuousness after R1 P1 peptide joint cavity injection DMM model mices is reduced into cartilage degeneration and matrix loss is horizontal, delays arthritic processes.And the polypeptide has the advantages that molecular weight is small, it is simple to prepare, quality controllable, immunogenicity is low etc., can prepare alleviation or treatment medicine for treating arthritis, there is good potential using value. |
| priorityDate | 2015-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.