| abstract |
The present invention relates to solid oral extended release pharmaceutical dosage forms (eg, tamper resistant dosage forms) comprising opioid analgesics, and methods for their preparation, use and treatment. The present invention provides a solid oral extended release pharmaceutical dosage form comprising an extended release matrix formulation comprising a composition comprising at least the following components: (1) at least one compound having an approximate molecular weight of at least 800,000 based on rheological measurements and (2) at least one active agent selected from opioid analgesics, and wherein the composition comprises at least about 80 wt % polyethylene oxide. |