http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105267165-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4422 |
| filingDate | 2014-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105267165-B |
| titleOfInvention | A kind of preparation method of Nitrendipine Tablet |
| abstract | The invention discloses a kind of preparation method of Nitrendipine Tablet, comprise the following steps：(1) 8 12 parts of nitrendipine, 45 55 parts of cellulose milk sugar, 10 14 parts of low-substituted hydroxypropyl cellulose, 1.8 parts of silica 1 .2,0.3 0.5 parts of magnesium stearate are weighed by weight；(2) cellulose milk sugar, low-substituted hydroxypropyl cellulose, silica are crossed into 100 140 mesh sieve 46 times respectively, mixing, nitrendipine is added into mixed-powder, it is well mixed, 100 140 mesh sieve 46 times are crossed, add magnesium stearate, with 25 30 revs/min of rotating speed, mix 20 30 minutes, obtain intermediate powder, the angle of repose for controlling intermediate powder is 21 23 degree；(3) intermediate powder is subjected to tabletting, tableting pressure 80KN, pellet diameter 5.5mm, depth of fill 3mm, obtains plain piece.The present invention carries out the preparation of tablet using direct powder compression, without high temperature drying, without softwood processed, avoids influence of the temperature and humidity factor to drug crystal forms, preferably maintains the advantage crystal formation of medicine. |
| priorityDate | 2014-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.