| abstract |
The present invention provides a nucleoside phosphoramidate derivative and its application, which is specifically a compound of formula I, or a pharmaceutically acceptable acid salt, solvate or hydrate thereof; wherein: R 1 is C 1-4 alkane R2 is an optionally substituted phenyl or naphthyl, and its substituents are selected from C 1-4 alkyl, C 1-4 alkoxy; R 3 is amino acid acyl or polypeptide acyl. The compound of the present invention can be used to prepare medicines for preventing or treating mammalian infectious diseases, especially for preparing medicines for preventing or treating hepatitis C, liver cirrhosis and liver cancer. |