http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105254632-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9ae09d7d2328d034e510ef46a62ae57 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D477-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D477-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-20 |
| filingDate | 2015-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3d59c1565a6784f7b46b7fc61783ff4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da38e67a010187931ba0f5f69611cf9e |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105254632-A |
| titleOfInvention | Preparation method of doripenem |
| abstract | The invention relates to a preparation method of doripenem. The method comprises the following steps: removing an acetyl group and a tert-butyloxycarbonyl group from an acetylthiopyrrolidine derivative (SM-1) used as an initial raw material to prepare a thiopyrrolidine derivative (DN-1), carrying out a nucleophilic substitution reaction on the DN-1 and a doripenem parent nucleus (SM-2, MAP) to prepare protected doripenem, carrying out catalytic hydrogenation to remove PNZ and PNB protection, and purifying to obtain final doripenem. A solvent and a catalyst used in the method can be recycled, so the production cost is greatly saved, and the method is suitable for large-scale industrial production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105541846-A |
| priorityDate | 2015-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.