| abstract |
Compounds of formula I are provided, wherein R 1A to R 1E , R 2 to R 5 , L and X 1 to X 3 have the meanings given in the specification, said compounds having anti-inflammatory activity (for example by inhibiting one or Multiple members: p38 mitogen-activated protein kinase family; Syk kinase; and members of the Src family of tyrosine kinases) and have therapeutic uses, including in drug combinations, particularly in the treatment of inflammatory diseases (including pulmonary , eye and intestinal inflammatory diseases). |