| abstract |
Provided herein are compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R 1 , R 1a , R 2a , R 2b , R 2c , R 2d are as defined herein , and Ring HET is a 6-membered monocyclic heteroaryl ring system having the following formula (II), wherein L 2 , R 13 , G 8 , G 10 , G 11 and G 12 are as defined herein. The compounds of the invention are useful for inhibiting CARM1 activity. Methods of using these compounds to treat CARM1 -mediated disorders are also described. |