| abstract |
The present invention provides a kind of PIM kinase inhibitor and its preparation method and application, structural formula is following general formula Compound I: The present invention also provides the stereoisomer of compound of formula I, tautomer and pharmaceutical salts.The compound of the present invention has apparent inhibiting effect to the activity of kinases.PIM kinase inhibitor of the invention, which can be used for preparing, treats or prevents the drugs such as cancer, autoimmune disease, allergic reaction disease or anti-organ transplant rejection.With biggish clinical value. |