| abstract |
The invention discloses a preparation method of benzylamine compounds, using arylmethane compounds as raw materials, including NBS bromination reaction to synthesize bromobenzyl compounds, N-hydrocarbylation reaction to synthesize 1-benzylpyrrolidine-2,5 - 3 steps of diketone compound and hydrolysis reaction to obtain benzylamine compound. The preparation method of the benzylamine compound of the present invention has a wide range of sources of raw materials, and the intermediates produced by the reaction do not need to be separated, thereby realizing the "one-pot stew" process, with simple operation, mild reaction conditions, high reaction yield, less waste, and convenient industrialization Production. |