| abstract |
The present application provides novel inhibition of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase agents, their metabolites and pharmaceutically acceptable salts or prodrugs. The present application also provides methods of making these compounds. A therapeutically effective amount of one or more compounds of formula (I) can be used to inhibit diseases caused by dysregulation of the kynurenine pathway. Compounds of formula (I) inhibit indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase enzymatic activity or expression. |