http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105200089-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00 |
| filingDate | 2015-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105200089-B |
| titleOfInvention | (S) -1- tertbutyloxycarbonyls -3- hydroxy piperidines preparation method and its device |
| abstract | Present invention is disclosed a kind of 3 hydroxy piperidine preparation methods of (S) 1 tertbutyloxycarbonyl, include the following steps, are added in filter membrane reactor after first mixing ketoreductase enzyme powder, coenzyme；Again by 3 piperidones of N Boc, isopropanol in stirring and dissolving in the first reaction kettle, and buffer solution is added and is stirred at 30 DEG C；The above solution is pumped into filter membrane reactor by flow pump and carries out hybrid reaction；The reaction solution of filter membrane reactor flows through the second reaction kettle and is post-processed；To treated that mixture extracted, concentrate, crystallize, 3 hydroxy piperidine of (S) 1 tertbutyloxycarbonyl is made.The present invention is larger using the molecular weight of ketoreductase and coenzyme, reaction substrate and the smaller feature of molecular weight of product, can simple and convenient recovery ketoreductase enzyme powder and coenzyme using filter membrane reactor.By controlling reaction solution material movement speed, the reaction time is shortened；Also simplify the aftertreatment technology of 3 hydroxy piperidine of (S) 1 tertbutyloxycarbonyl production；To which 3 hydroxy piperidine manufacturing cost of (S) 1 tertbutyloxycarbonyl be greatly reduced. |
| priorityDate | 2015-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 254.