http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105198873-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcaa03b795cd8da869d58e8f28bf52e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10c3f12979e7751f6e54ae5594988766 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-02 |
| filingDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7957baa759110a2359651b4a99e4bb98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb65e476e00b6f4ec8d33d87c8848d36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9602025613e99cdc4111e7161c959bdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1505e4cd754f0aee3c27c3928e8a4795 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e568f857610d7481a3bab4c09524aec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4db86953bca99440638e9a01fdce1235 |
| publicationDate | 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105198873-A |
| titleOfInvention | A kind of method for preparing retapamulin |
| abstract | The invention discloses a method for preparing retapamulin, comprising the following steps: the compound of formula 3 and the compound of formula 4 undergo a nucleophilic substitution reaction to obtain the compound shown in formula 5; the compound of formula 5 undergoes a hydrolysis reaction to obtain the β- Tropine thiol; β-tropine thiol shown in formula 6 is not separated and purified and condensed with the compound shown in formula 2 under alkaline conditions to obtain retapamulin 1; the reaction formula is as follows: Wherein, in the compound of formula 4, M is a metal ion selected from potassium ions, sodium ions, calcium ions, iron ions or ammonium ions; n corresponds to the valence of the metal ion M, which is 1, 2 or 3; R is selected from C1- C3 alkyl, phenyl, substituted phenyl, benzyl or substituted benzyl. The present invention is easy to operate, uses cheap reagents, greatly reduces the impact on the environment, the intermediate product is easy to purify, does not need column chromatography, overcomes the defects and deficiencies of the reported methods for preparing β-tropine thiol and retapamulin, and has obvious advantages The positive progress effect and practical application value. |
| priorityDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467942175 |
Total number of triples: 17.