| abstract |
The invention discloses a preparation method of substituted biphenyl, which comprises the following steps: under anhydrous conditions, in a solvent, in the presence of Ni salt and ZnX 3 X 4 , compound 2 and compound 3 are coupled reaction to obtain substituted biphenyls; the Ni salts are NiX 5 X 6 (PPh 3 ) 2 , NiX 7 X 8 (dppp), NiX 9 X 10 (dppf), NiX 11 X 12 (dppe) and acetyl One or more of nickel acetonate; the temperature of the coupling reaction is 0-30°C; before the mixing of the compound 2 and the compound 3, the ZnX 3 X 4 and the Compound 3 was mixed. The method has mild reaction conditions, simple process, safe operation, low equipment requirements, simple post-treatment, little environmental pollution, easy industrial production, low zinc halide consumption, low cost, high yield and high product purity. |