http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105193721-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-215 |
| filingDate | 2015-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105193721-B |
| titleOfInvention | A kind of fowl nanoscale water-in-oil type inactivated vaccine preparation method |
| abstract | The present invention provides a kind of fowl nanoscale water-in-oil type inactivated vaccine preparation methods, the method that this method is concentrated using multistage continuous purification, the filtering of different stage is carried out using the hollow fiber ultrafiltration membrane of tube centrifuge and different pore size, macromolecular and small molecular weight impurity are retained, takes out the higher antigenic solution of purity.Meanwhile nanoscale emulsification is carried out to inactivated vaccine by the way of colloid mill and homogenizer continuous emulsification, inactivated vaccine Water-In-Oil particle is made to reach Nano grade, the uniformity is good.Conventional colloid mill circulating emulsion makes inactivated vaccine reach conventional character requirement 2~3 times, then high pressure homogenizer inlet is connected by pipeline, circulating emulsion 3~4 times in homogenizer, reach 100nm ranks, the cooling device of homogenizer connection simultaneously, the temperature in vaccine emulsion process is reduced, ensures the effect of vaccine.In addition, adding immunopotentiator in the mistake that water is mutually prepared, help to promote immune effect of vaccine. |
| priorityDate | 2015-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.