http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105177048-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-864 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 |
| filingDate | 2015-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105177048-B |
| titleOfInvention | Recombinant adeno-associated virus vector carrying human papillomavirus type 16 multi-point mutant E7mm antigen gene and its construction method and application |
| abstract | The present invention carries the recombinant adeno-associated virus vector of HPV-16 E7 mm antigen gene and its construction method, which is to mutate the E7 antigen gene of tumorigenic HPV-16 into non-tumorigenic E7 antigen gene, and then The mutated gene is inserted into the adeno-associated virus vector in which the structural gene has been deleted. The recombinant adeno-associated virus can deliver the mutant HPV-16 E7 mm antigen gene carried by it into the monocyte-dendritic cell line, which is used to stimulate the effector cells of the immune system. Experiments have proved that CTLs induced by DCs infected with this group of adeno-associated viruses can effectively inhibit the growth of HPV-16 E7-positive cells or kill HPV-16 E7-positive cells in vitro and in patients, and have no tumorigenicity . The recombinant adeno-associated virus vector or related products of the present invention can be used to prepare antitumor drugs for treating HPV‑16 infection and related products. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111088286-A |
| priorityDate | 2014-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 225.