http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105175474-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ecd7669eb26b9d6fa05b5901a0f2e5d6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be0f53c778f16183eb41a6edfbc797bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_033f67095faf0cffed375b80fcad77aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_769ef95786c891caba9ecf7d1199e7f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45b547a672fd6d0bcde9a1ec0d3c6b91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_203c9af62cf983414a83402c7a682092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05b9d093c4cc27b087bdb48cd979f682 |
| publicationDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105175474-A |
| titleOfInvention | Abiraterone purifying method |
| abstract | The invention discloses an abiraterone purifying method, belongs to the technical field of pharmacy synthesis technologies, and concretely relates to an abiraterone purifying method. Abiraterone is an important intermediate of abiraterone acetate. Column chromatography for abiraterone purification in known abiraterone synthesis methods has the disadvantages of time consumption and high cost, and is a bottleneck in the large scale production for preparing abiraterone acetate, so searching of a simple and feasible abiraterone purifying method is necessary. The method comprises the following steps: reacting crude abiraterone with an acid to form a salt, re-crystallizing in an appropriate solvent, and adding an alkali to dissociate in order to obtain purified abiraterone with the HPLC purity being greater than 99.5% and the single impurity content being smaller than 0.1%. The method has the advantages of simple process, easy control and high crystallization yield, so the method has very strong industrial prospect. |
| priorityDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.