http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105153412-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G69-14 |
| filingDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105153412-B |
| titleOfInvention | A kind of polypeptide block polymer and preparation method thereof, purposes |
| abstract | The invention belongs to polymer chemistry and biomedical engineering technology field, and in particular to a kind of polypeptide block polymer and preparation method thereof, purposes.Molecular formula is：PLAsp(DIP) n ‑b‑PLLys m .Preparation process：(1) N ε benzyloxycarbonyl group lysine benzyl esters are synthesized；(2) N ε benzyloxycarbonyl group lysine anhydride CBLLys NCA are synthesized；(3) β aspartic acid benzyl esters are synthesized；(4) β aspartic acid anhydride BLAsp NCA are synthesized；(5) Bu PBLAsp are synthesized n ；(6) synthesize PBLAsp n ‑b‑PCBLLys m ；(7) synthesize PLAsp (DIP) n ‑b‑PCBLLys m ；(8) synthesize PLAsp (DIP) n ‑b‑PLLys m .Purposes of the polypeptide block polymer as drug delivery carrier.Polypeptide block polymer of the present invention is self-assembly of vesicle system, can be used as medication combined transport vehicle, and the vesicle system is sensitive to pH, can reach Synergistic with simultaneous transmission chemicalses and genomic medicine；The carrier is made up of many peptide units, good biocompatibility, small toxicity, and the carrier can be integrated with gene therapy so as to realize carrier positioning, chemotherapy with two kinds of medicines of joint transmission, is with a wide range of applications. |
| priorityDate | 2015-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.