| abstract |
The invention discloses a derivative of D-p-hydroxyphenylglycine, which has the following structural formula. The invention uses D-p-hydroxyphenylglycine as the matrix, reasonably modifies its amino group and carboxyl group, and passes a linker on the phenolic hydroxyl group Linked with an aromatic ring hydrophobic group, a class of novel D-hydroxyphenylglycine derivatives was constructed, and compounds with GLP-1 secretion-promoting activity and/or Nav1.7 inhibitory activity were screened out. These compounds The preparation method is simple, can be used to prepare GLP-1 secretion promoters and/or Nav1.7 inhibitors, and has potential application prospects in the fields of drugs for treating diabetes and/or drugs for treating neuropathic pain. |