http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105152934-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43e689f175057f56c04ebbccf59f8abe |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-343 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 2015-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_487a1c804e613a4a070d218e2741d81e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2776380152c97bae0af422439c8ca2a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1241edfe38fc8a78bf2f967ba779c245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc7a210ecb5ade3cddf4f799baff3461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9730cec03c84ea476eda787b8f025f31 |
| publicationDate | 2015-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105152934-A |
| titleOfInvention | Catalytic asymmetric synthesis of axial chiral biaryl diphenols |
| abstract | The invention discloses a method for catalyzing the asymmetric synthesis of axial chiral biaryl diphenols. In an organic solvent, using chiral phosphoric acid as a catalyst, the compound of formula I and the compound of formula II are reacted to obtain the compound of formula III: wherein, R 1 is an alkane Oxygen, ester, halogen, alkyl, hydroxyl, aryl, aldehyde or amide ; R2 is alkoxy, cyano, ester, alkyl, aryl, halogen or H. The present invention uses simple and easy-to-prepare raw materials under mild reaction conditions to synthesize axial chiral biaryl diphenols with high yield; the synthetic method of the present invention has good enantioselectivity, and the ee value of the obtained product Very high; the synthetic method of the present invention can tolerate multiple functional groups, and the substituent of 2-naphthol can be an electron-withdrawing substituent or an electron-donating substituent; the source of the catalyst used in the present invention is convenient, without heavy metal pollution, and has the prospect of realizing industrialization . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501160-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501163-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501160-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107501163-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105859527-A |
| priorityDate | 2015-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.