http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105148286-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105148286-B |
| titleOfInvention | The preparation method of the compound drug-loading nanoparticles of silk gum/mesoporous silicon of sericin parcel |
| abstract | The present invention relates to nanometer pharmaceutical carrier of natural sericin parcel and preparation method thereof and in the application of therapeutic field of tumor, its preparation method includes：Prepare pure silk glue protein solid；Prepare nanometer particle；Prepare amination, aldehyde radical or double vulcanization nanometer particles with regular pore canal；Prepare amination, aldehyde radical or the double vulcanization nanometer particles of carrying medicament；Prepare silk gum/mesoporous silicon composite multi-functional control system of pH/ protease or reduction/protease double responsiveness.The present invention is simple to operate, and raw material acquisition pattern is easy, with low cost, is generally applicable, without Special complex equipment etc..Use the nano composite system prepared by this method, take full advantage of the characteristic of outer layer sericin and internal layer nanometer particle, with pH/ protease or reduction/protease dual responsiveness, possesses suppression tumour cell, the multi-functionals such as nano-particle positioning and insoluble drug release are monitored in real time, and drugloading rate is high, good biocompatibility is particularly in tumour diagnosis and treatment field and possesses wide application prospect in terms of the multi-drug resistant of tumour is solved. |
| priorityDate | 2015-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.