http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105142662-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-904 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57496 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-43 |
| filingDate | 2013-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105142662-B |
| titleOfInvention | IDH1 R132H mutation positive cancer treatments or the means and method of diagnosis |
| abstract | The present invention relates to oncotherapy and diagnostic field.Specifically, the present invention relates to a kind of comprising at least 8 peptides of the amino acid length being present in continuous amino acid sequence form in I type people's isocitric dehydrogenases, at least one amino acid of wherein described peptide is replaced into H on the site corresponding with 132 sites by R, for prevention and/or treating cancer.The present invention is it is further contemplated that be the medicament comprising the peptide.Moreover, it relates to a kind of diagnose the method for having the characteristics that cancer：The genome of at least some cancer cells is undergone mutation, and causes the IDH1 mutant with R132H mutation to be expressed, and the method comprises the following steps：Suspect the blood sample with tumour subject using being contacted comprising at least 10 peptides of the amino acid length being present in continuous amino acid sequence form in IDH1, wherein immune system components are being allowed to be specifically bound on peptide and can determine that whether the mentioned component of immune system is attached to a period of time and the condition on peptide, at least one amino acid of the peptide is replaced into H on the site corresponding with 132 sites by R, wherein can just diagnose cancer if it is determined that occurring to combine.The present invention also provides the kit and device for implementing the method. |
| priorityDate | 2012-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.