| abstract |
Compounds of formula I are disclosed herein: Or its stereoisomer, tautomer or pharmaceutically acceptable salt, or solvate or prodrug, wherein R 1 , R 2 , R a , R b , R c , R d , X, Y , B and ring C are as defined herein, and wherein said YB moiety and said NH-C(=X)-NH moiety are in trans configuration, said compound is a TrkA kinase inhibitor and is suitable for use in the treatment of TrkA Kinase inhibitors treat diseases such as pain, cancer, inflammation, neurodegenerative diseases, and certain infectious diseases. |