http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105130955-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105130955-B |
| titleOfInvention | The preparation method of Vonoprazan fumarate |
| abstract | The invention discloses the preparation methods of Vonoprazan fumarate; 5 (2 fluorophenyl) 1 (3 sulfonyl of pyridine) 1H pyrroles, 3 formaldehyde is dissolved in solvent; methylamine gas is filled at 20 30 DEG C; stirring; be cooled to 05 DEG C, add in reducing agent, after continue stirring until the reaction is complete; grease is handled to obtain, fumaric acid is added in and obtains Vonoprazan fumarate crude product into salt；Crude product is added in the in the mixed solvent of methanol and N, N dimethylformamide, being heated to 60 70 DEG C dissolves solid, filtering, and cooling, crystallization filter, dry white crystals.The preparation method of the present invention can reduce the generation of byproduct of reaction, and high-purity Vonoprazan fumarate is obtained using new process for refining, and detecting Vonoprazan fumarate purity by HPLC reaches 99.8%. |
| priorityDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.