http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105111197-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105111197-B |
| titleOfInvention | Synthesis method of raltitrexed |
| abstract | The invention provides two methods for preparing a compound shown in a formula 4, wherein in the first scheme, 5-bromothiophene-2-methyl formate is used as a raw material to react with 6- ((methylamino) methyl) -3, 4-dihydro-2-methyl-4-oxo-6-quinazoline (compound 1) to prepare 2- [ N- (2-methyl-4-oxoquinazoline-6-methyl) -N-methyl]The-aminothiophene-2-methyl formate is hydrolyzed in an aqueous solution of alkali and then undergoes a condensation reaction with L-diethyl glutamate to prepare a compound shown in a formula 4; in the second scheme, 5-bromothiophene-2-formic acid is used as a raw material and is condensed with L-glutamic acid diester to prepare N- (5-bromothiophene-2-yl) diethyl glutamate, and then the N- (5-bromothiophene-2-yl) diethyl glutamate reacts with the compound of the formula 1 to prepare a compound of a formula 4; the invention also provides a method for preparing raltitrexed, wherein the compound in the formula 4 is hydrolyzed in aqueous solution of alkali, and then is acidified by hydrochloric acid to prepare the raltitrexed. The synthesis route adopted by the invention has the advantages of few reaction steps, simple and convenient operation, little environmental pollution and high product yield. |
| priorityDate | 2015-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.