http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105085437-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 |
| filingDate | 2014-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105085437-B |
| titleOfInvention | Amphipathic derivatives of 3- (1- tert-butoxy carbonyl piperazines -4-yl) propionic acid and application thereof |
| abstract | The present invention relates to a kind of amphipathic derivatives of 3 (1 tert-butoxy carbonyl piperazine, 4 yl) propionic acid and application thereof；The invention further relates to the liposomes by the amphipathic derivatives object preparation；The purposes is purposes of the liposome as pharmaceutical carrier transport system.The liposome that is prepared of amphipathic derivatives object of the present invention, with genomic medicine siRNA it is compound after, the compound that grain size is smaller, is evenly distributed can be formed.The internal stability of lipid complex is increased, reduces the cytotoxicity caused by excessive positive charge in electroneutral under pH7.4 environment simultaneously.Liposome provided by the invention, can In-vitro specificity inhibit Non-small cell lung carcinoma H1299 Pgl3 cells gene expression, and can in vivo specificity reprinting fluorogene drug enter normal mouse liver cell. |
| priorityDate | 2014-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.