| abstract |
The present invention relates to technical field of chemical medicine, specifically disclose a kind of benzo [d] isoxazole class compound and its application shown in general formula (A).Such compound can effectively inhibit the bromine structural domain (bromodomain) of BET family proteins, so as to block the interaction between BET family proteins and chromatin histone, and then genetic transcription is adjusted, cause the variation of downstream signaling pathway, and a variety of diseases are had an important influence on.Therefore compound provided by the invention and composition can be used for preparing the drug for treating or preventing the diseases such as tumour formation, inflammation, viral infection, cell proliferation sexual disorder, autoimmune disease, septicemia. (A)。 |