http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105079785-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105079785-B |
| titleOfInvention | Three domain protein 32(TRIM32) treating function and application in myocardial hypertrophy |
| abstract | The invention discloses three domain protein 32(TRIM32 of one kind) function and application in myocardial hypertrophy are being treated, belong to the function and application field of gene.Present invention determine that the correlation between the expression and myocardial hypertrophy of TRIM32, result of study shows in the model that myocardial hypertrophy occurs, and the expression of TRIM32 and normally organizes and compares significant decrease；Inhibit TRIM32 expression to significantly promote the activation of AKT signal path, promote myocardial hypertrophy, fibrosis, deteriorates heart function；TRIM32 is promoted to be overexpressed the activation for then significantly suppressing AKT signal path, it is suppressed that myocardial hypertrophy, fibrosis protect heart function.Therefore, TRIM32 can be used as target gene, for screening or preparing cardioprotection function, anti-cardiac fibrosis and/or prevention, alleviation and/or the drug for treating myocardial hypertrophy, provide an effective new way for the treatment of myocardial hypertrophy. |
| priorityDate | 2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 406.