http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105079780-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2014-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105079780-B |
| titleOfInvention | Application of polypeptide specifically binding TRB3 in treatment of abdominal aortic aneurysm |
| abstract | The invention discloses an application of a polypeptide capable of specifically binding TRB3 or a derivative of the polypeptide in preparing a medicament for treating abdominal aortic aneurysm; the amino acid sequence of the polypeptide is shown as SEQ ID NO: 1; the derivative of the polypeptide is a chimeric peptide formed by connecting the polypeptide and cell-penetrating peptide and/or an administration dosage form formed by matching the polypeptide with a pharmaceutical adjuvant. The polypeptide is screened by a surface plasmon resonance (Biacore) method, has the specific binding with TRB3 and can block the binding capacity of TRB3 and P62 proteins; meanwhile, the derivative Pep2-A2 of the peptide fragment can treat the apoE knockout mouse abdominal aortic aneurysm induced by angiotensin II. Therefore, the derivative of the invention can be used as a novel TRB3 inhibitor and can be applied to the development of vaccines or medicaments for inhibiting the abdominal aortic aneurysm. |
| priorityDate | 2014-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 444.