http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105062976-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90241 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6897 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105062976-B |
| titleOfInvention | The stem cell screening model of sitaxsentan sodium thing and application |
| abstract | The invention belongs to the technology of pulmonary hypertension new types of therapeutic agents screening is established using stem cells technology, using BMP signals downstream key gene Id1 genes as target spot, the double reporter gene original paper insertion Id1 genomes structure recombinant vectors of design, and it is transferred to human embryo stem cell strain, obtain the cell line for the CGMCC11091 for stablizing expression, the compound of anti-pulmonary hypertension to be measured is stimulated to the cell line of CGMCC11091, cell pyrolysis liquid cell lysis is used again, by gene detection system the method detection luciferase expression activity, index is used as using double reporter gene expression amounts of Id1 promoters driving, obtain the screening model of the treatment pulmonary hypertension compound to Id1 up-regulated expressions, present invention additionally comprises model to raise the conditioning agent of bone morphogenetic protein (BMP) signal；Raise the conditioning agent of bone morphogenetic protein II receptor expressions；Improve the dynamic (dynamical) preparation of pulmonary artery flow；Improve the preparation of pulmonary artery remodeling；Application in sitaxsentan sodium thing and the screening of cardiopulmonary and vascular disease medicine. |
| priorityDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.